Researcher Position in Proteomics and Genomics at the University of Copenhagen
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Researcher Position in Proteomics and Genomics at the University of Copenhagen
A researcher position is available in the Choudhary group at the University of Copenhagen.
About the groups
The Choudhary lab is technically and internationally diverse and embedded in an excellent environment that supports high-quality research and encourages interdisciplinary collaboration. The Choudhary lab conducts research using interdisciplinary, state-of-the-art technologies, including quantitative proteomics, next-generation nucleic acid sequencing, advanced microscopy, CRISPR-based genome editing, and bioinformatics. The lab uses diverse cell models, including embryonic stem cells and their differentiated derivatives.
We are now looking for a researcher with a PhD and/or MD (i.e. level of education corresponding to the Danish PhD degree).
Project description
Our group works in the broad areas of proteomics, genomics, and cell signaling. In this project, we are interested in understanding the scope and function of lysine acetylation in gene regulation, as well as understanding the mechanisms of gene activation by cis-regulatory enhancers. The project will use quantitative proteomics and genomics to further understand the role of acetylation and other chromatin modifications in gene regulation. The project will combine CRISPR-based genome editing with mapping of protein proximity landscape using AEPX2 and miniTurboID-based proximity-based labeling and quantitative mass spectrometry. Furthermore, the project will utilize degron-based acute protein depletion and NGS-based approaches (i.e. EU-seq and ChIP-seq) to uncover new regulatory pathways and decipher underlying mechanisms.
The postdoc candidate will perform wet laboratory experiments involving cultured mammalian cells, creating CRISPR-engineered cell lines and generating data using quantitative imaging, mass spectrometry-based proteomics, and next-generation sequencing. The candidate with experience in both wet lab and bioinformatics will be able to do both (i.e. work in the wet lab and perform bioinformatics analyses).
Qualifications
The candidate should have demonstrated excellent scientific productivity, evidenced by high-quality research publications, be able to conduct independent and creative research and show good interpersonal and communication skills.
Place of employment and work
The employment is at CPR (www.cpr.ku.dk), University of Copenhagen, located in central Copenhagen. The Center comprises modern laboratories, supercomputer resources, and state-of-the-art research facilities. Denmark is often ranked as the happiest nation and Copenhagen is consistently ranked as one of the best cities for living. For more information on working and living in Denmark visit www.ism.ku.dk (International staff mobility) and www.workingconditions.ku.dk.
Terms of salary and employment
Salary, pension, and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Depending on qualifications, a supplement may be negotiated.
The Danish Ministry of Finance and the Danish Confederation of Professional Associations (AC) have agreed on a protocol that makes it possible for all international researchers employed by the University to achieve a pension exemption, where the pension can be paid out as salary. For more information about the different pension schemes www.ism.ku.dk/onarrival/pension/
Duration: The duration of the full-time position is 2 years
Start date: August 14, 2025
Application procedure
Your application must be submitted electronically by clicking ‘APPLY NOW’ below or via this advertisement found at http://employment.ku.dk/faculty/
Your application should include the following documents:
1. Cover letter
2. Curriculum vitae, incl. educational qualifications, experience, and a list of publications
3. A scanned copy of the final degree (PhD or equivalent) certificate.
4. Names and contact details for 2-3 referees
The applicants can submit these materials in the given fields in the online submission system. We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above-mentioned requirements.
Deadline for applications: Wednesday 4 June 2025, 23.59pm CEST
The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
The University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.
About the groups
The Choudhary lab is technically and internationally diverse and embedded in an excellent environment that supports high-quality research and encourages interdisciplinary collaboration. The Choudhary lab conducts research using interdisciplinary, state-of-the-art technologies, including quantitative proteomics, next-generation nucleic acid sequencing, advanced microscopy, CRISPR-based genome editing, and bioinformatics. The lab uses diverse cell models, including embryonic stem cells and their differentiated derivatives.
We are now looking for a researcher with a PhD and/or MD (i.e. level of education corresponding to the Danish PhD degree).
Project description
Our group works in the broad areas of proteomics, genomics, and cell signaling. In this project, we are interested in understanding the scope and function of lysine acetylation in gene regulation, as well as understanding the mechanisms of gene activation by cis-regulatory enhancers. The project will use quantitative proteomics and genomics to further understand the role of acetylation and other chromatin modifications in gene regulation. The project will combine CRISPR-based genome editing with mapping of protein proximity landscape using AEPX2 and miniTurboID-based proximity-based labeling and quantitative mass spectrometry. Furthermore, the project will utilize degron-based acute protein depletion and NGS-based approaches (i.e. EU-seq and ChIP-seq) to uncover new regulatory pathways and decipher underlying mechanisms.
The postdoc candidate will perform wet laboratory experiments involving cultured mammalian cells, creating CRISPR-engineered cell lines and generating data using quantitative imaging, mass spectrometry-based proteomics, and next-generation sequencing. The candidate with experience in both wet lab and bioinformatics will be able to do both (i.e. work in the wet lab and perform bioinformatics analyses).
Qualifications
The candidate should have demonstrated excellent scientific productivity, evidenced by high-quality research publications, be able to conduct independent and creative research and show good interpersonal and communication skills.
- The candidate is required to have a PhD/MD level of education corresponding to the Danish PhD degree in natural or medical science.
- Excellent scientific track record, including at least one publication in a high-quality, peer-reviewed international journal. Pre-prints can be counted for fulfilling this requirement.
- Expert knowledge in one or more of the following areas is advantageous:
- Prior experience in the area of epigenetics, and gene transcription regulation.
- Experience in molecular biology techniques, including the use of CRISPR-based genome editing.
- Hands-on experience in high-resolution mass spectrometry and proximity-based interaction analyses is essential.
- Hands-on experience in quantitative imaging and culturing mammalian cells.
- Good communication skills, both oral and written.
- An analytical aptitude for devising innovative scientific or technical solutions.
Place of employment and work
The employment is at CPR (www.cpr.ku.dk), University of Copenhagen, located in central Copenhagen. The Center comprises modern laboratories, supercomputer resources, and state-of-the-art research facilities. Denmark is often ranked as the happiest nation and Copenhagen is consistently ranked as one of the best cities for living. For more information on working and living in Denmark visit www.ism.ku.dk (International staff mobility) and www.workingconditions.ku.dk.
Terms of salary and employment
Salary, pension, and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Depending on qualifications, a supplement may be negotiated.
The Danish Ministry of Finance and the Danish Confederation of Professional Associations (AC) have agreed on a protocol that makes it possible for all international researchers employed by the University to achieve a pension exemption, where the pension can be paid out as salary. For more information about the different pension schemes www.ism.ku.dk/onarrival/pension/
Duration: The duration of the full-time position is 2 years
Start date: August 14, 2025
Application procedure
Your application must be submitted electronically by clicking ‘APPLY NOW’ below or via this advertisement found at http://employment.ku.dk/faculty/
Your application should include the following documents:
1. Cover letter
2. Curriculum vitae, incl. educational qualifications, experience, and a list of publications
3. A scanned copy of the final degree (PhD or equivalent) certificate.
4. Names and contact details for 2-3 referees
The applicants can submit these materials in the given fields in the online submission system. We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above-mentioned requirements.
Deadline for applications: Wednesday 4 June 2025, 23.59pm CEST
The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
The University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.