Staff Scientist (AC-TAP) in mass spectrometry for quantitative proteomics at Center for Proteomics Research
fuldtid
Staff Scientist (AC-TAP) in mass spectrometry for quantitative proteomics at Center for Proteomics Research
Department Faculty of Health and Medical Sciences
University of Copenhagen
We are looking for a minimum of two highly motivated and independent staff scientists to support our efforts in mass spectrometry for quantitative proteomics to commence April 1, 2026, or after agreement.
Our research
Olsen Group
We offer a vibrant, ambitious and international research environment, as well as access to cutting-edge facilities within protein science. We address unsolved questions in cell signalling. The group aims to characterize how signalling networks regulate cellular responses differentially when mediated by phosphorylation and other modifications. The major scientific focus area for us is quantitative, high-resolution mass spectrometry-based proteomics with specific emphasis on mass-spectrometric technology developments for single-cell proteomics and its biological applications.
We have a long-standing interest in applying proteomics technology developments to systems-wide analyses of dynamic post-translational modifications such as site-specific phosphorylation that regulate essentially all cellular signal transduction pathways. Offline peptide fractionation and enrichment methods combined with high-resolution Orbitrap Astral tandem mass spectrometry acquisition strategies are continuously developed by us with the aim to be more robust, reproducible, and rapid.
We are part of national and international collaboration networks. The candidates will be part of the Danish National Research Foundation Center for Glycocalyx Research (GCR) and work as part of the project teams on the ERC-synergy grant project ‘ADIPOHealth’ or the NNF Laureate research grant project on single-cell proteomics to study PTMs in health and disease.
Your job
You will join a multi-disciplinary research team working on proteomics sample preparation, peptide separation, MS acquisition methods and computational proteomics strategies.
You will be expected to contribute to and support the ongoing research projects in the group on an ad hoc basis when needed; disseminate your expertise to new lab members and support the lab management.
Your tasks will include the following depending on your specific experience and skills:
We are looking for highly motivated and enthusiastic staff scientists with the following competencies and experience:
Essential experience and skills – all candidates
Essential experience and skills – research profile 1
The place of employment is at the Department of Cellular and Molecular Medicine, Panum, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment.
You will be part of two centers, Novo Nordisk Foundation Center for Protein Research (CPR) and the Copenhagen Center for Glycocalyx Research (CGR). CPR promotes basic and applied discovery research on human proteins with medical relevance and is a strong hub for research on genome stability maintenance and human disease, comprising modern laboratories and state-of-the-art facilities within protein science. CGR aims to uncover the vital role of the glycocalyx, a cell surface layer of complex glycans, that integrates signals from cells and their environment, and CGR’s research facilities include modern laboratories located in the Mærsk tower with access to state-of-the-art facilities for cell engineering, next-generation sequencing, flow cytometry, and mass spectrometry.
Scientific environment
The Department of Cellular and Molecular Medicine (ICMM) offers an ambitious scientific environment, with many different nationalities represented. ICMM aims to produce research with high international impact focusing on the functional cell, its genetic components and molecular cellular mechanisms in a medical context. ICMM currently comprises five research programs, three high profile Research Centers as well as a number of international research groups.
https://icmm.ku.dk/english/
Terms of employment
The average weekly working hours are 37 hours per week.
The position is a fixed-term position limited to a period of around 5 years depending on the start date. The start date is April 1, 2026, or after agreement.
Employment will be in accordance with the provisions of the collective agreement between the Danish Ministry of Finance and AC (the Danish Confederation of Professional Associations). The monthly salary will be based on the number of years of work experience (seniority) with the possibility to negotiate a salary supplement based on prior experience and qualifications. The employer will pay an additional 18,07% to your pension fund.
Questions
For further information regarding the position, please contact Jesper V. Olsen, jesper.olsen@cpr.ku.dk
Application
Your application should in [English/Danish] include:
Application deadline: Sunday 4 January 2026 23.59 CET
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
Interviews are expected to be held in weeks 4 and 5
The University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.
University of Copenhagen
We are looking for a minimum of two highly motivated and independent staff scientists to support our efforts in mass spectrometry for quantitative proteomics to commence April 1, 2026, or after agreement.
Our research
Olsen Group
We offer a vibrant, ambitious and international research environment, as well as access to cutting-edge facilities within protein science. We address unsolved questions in cell signalling. The group aims to characterize how signalling networks regulate cellular responses differentially when mediated by phosphorylation and other modifications. The major scientific focus area for us is quantitative, high-resolution mass spectrometry-based proteomics with specific emphasis on mass-spectrometric technology developments for single-cell proteomics and its biological applications.
We have a long-standing interest in applying proteomics technology developments to systems-wide analyses of dynamic post-translational modifications such as site-specific phosphorylation that regulate essentially all cellular signal transduction pathways. Offline peptide fractionation and enrichment methods combined with high-resolution Orbitrap Astral tandem mass spectrometry acquisition strategies are continuously developed by us with the aim to be more robust, reproducible, and rapid.
We are part of national and international collaboration networks. The candidates will be part of the Danish National Research Foundation Center for Glycocalyx Research (GCR) and work as part of the project teams on the ERC-synergy grant project ‘ADIPOHealth’ or the NNF Laureate research grant project on single-cell proteomics to study PTMs in health and disease.
Your job
You will join a multi-disciplinary research team working on proteomics sample preparation, peptide separation, MS acquisition methods and computational proteomics strategies.
You will be expected to contribute to and support the ongoing research projects in the group on an ad hoc basis when needed; disseminate your expertise to new lab members and support the lab management.
Your tasks will include the following depending on your specific experience and skills:
- In charge of technical support and hands-on training for Olsen group members in advanced proteomics and MS technologies.
- Responsible for further development of experimental strategies and analytical tools for high-sensitivity proteomics and PTM analyses.
- Contribute significantly to experimental design, data analysis and dissemination of results.
- Responsible for other day-to-day tasks within the lab.
- Contribute to scientific deliverables and reporting in relation to funding agencies.
- Prepare scientific reports, journal articles and grant applications.
We are looking for highly motivated and enthusiastic staff scientists with the following competencies and experience:
Essential experience and skills – all candidates
- You have a Master's degree and preferably a PhD in Life Sciences or related
- Strong scientific track record, documented by high-quality publications in peer-reviewed international journals
- Extensive hands-on experience with methodologies in the areas of proteomics, cell biology and biochemistry
- You have proven the ability to envision, plan and execute a research project
- Good English skills, written and spoken
- Excellent organizational and inter-personal skills
- Enthusiasm, motivation, flexibility and confidence
- At least ten years of hands-on experience using contemporary mass spectrometers in a research setting
- Experience and knowledge in mass spectrometry-based proteomics using Orbitrap Astral Zoom MS
- Technology-driven mind-set
Essential experience and skills – research profile 1
- You have documented experience in mass spectrometry-based proteomics, and analysis of extracellular vesicles
- You have documented experience working with clinical samples (plasma, CSF and tissue) and collaboration with clinicians
- Prior experience in developing proteomics based workflows for isolation and characterization of extracellular vesicles and with magnetic-bead-based enrichment/depletion of plasma for proteome analysis
- Prior experience in bioinformatics analysis of proteomics data
- You have an active interest in secretome analysis and disease biomarker discovery in bodyfluids and spent cell culture media
- You have documented experience in application of mass spectrometry (MS)-based proteomics for analysis of post-translational modifications (PTMs)
- Prior experience and active interest in developing methods for the purification and MS-based analysis of various PTMs
- Extensive and proven experience with both data-dependent and data-independent acquisition methodology
- Experience with evaluation of cutting-edge mass spectrometry hardware, and optimization and development of standard operating procedures for new equipment
- Prior experience and active interest in developing proteomic methods for high-sensitivity single-cell proteomics
- Proven experience in analysis of various types of MS data using different search engine software (MaxQuant, DIA-NN, Spectronaut, Skyline, Proteome Discoverer, etc)
- Proven experience in bioinformatics analysis, visualization, and presentation of proteomics data
- Supervision experience, both formal supervision of (PhD) students, and providing general support to other researchers in the group
- Collaborative mind set, proven track record of providing MS access or consult, ranging from local to international
- You have documented experience in application of mass spectrometry (MS)-based proteomics, for analysis of post-translational modifications
- Prior experience with MS-based proteomics analysis of labile PTMs including ADP-ribosylation
- Proven experience studying labile PTMs using electron transfer dissociation-based fragmentation mass spectrometry
- Proven experience in analysis of data-dependent acquisition data resulting from MS analysis of labile PTMs, using different search engine software (MaxQuant, Skyline, Proteome Discoverer, etc)
- Collaborative mind set, specifically in the context of labile PTMs such as ADP-ribosylation, with a proven track record
- Prior experience and active interest in development and application of proteomic methods for high-sensitivity single-cell proteomics
- Proven experience in bioinformatics analysis, visualization, and presentation of proteomics data
- Documented experience and active interest in supervision of students in the context of MS-based proteomics
- Track record and active interest in teaching and organization of proteomics courses
- You have documented experience in mass spectrometry-based proteomics with specific expertise in spatial-proteomics of FFPE samples using deep visual proteomics.
- Prior experience in developing proteomic methods for high-sensitivity spatial-proteomics
- Prior experience in bioinformatics analysis of spatial-proteomics data
- You have an active interest in LC-MS/MS optimization
- Collaborative mind set, specifically in the context of spatial-proteomics, with a proven track record
- Proven experience in bioinformatics analysis, visualization, and presentation of proteomics data
- Documented experience and active interest in supervision of students in the context of MS-based proteomics
The place of employment is at the Department of Cellular and Molecular Medicine, Panum, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment.
You will be part of two centers, Novo Nordisk Foundation Center for Protein Research (CPR) and the Copenhagen Center for Glycocalyx Research (CGR). CPR promotes basic and applied discovery research on human proteins with medical relevance and is a strong hub for research on genome stability maintenance and human disease, comprising modern laboratories and state-of-the-art facilities within protein science. CGR aims to uncover the vital role of the glycocalyx, a cell surface layer of complex glycans, that integrates signals from cells and their environment, and CGR’s research facilities include modern laboratories located in the Mærsk tower with access to state-of-the-art facilities for cell engineering, next-generation sequencing, flow cytometry, and mass spectrometry.
Scientific environment
The Department of Cellular and Molecular Medicine (ICMM) offers an ambitious scientific environment, with many different nationalities represented. ICMM aims to produce research with high international impact focusing on the functional cell, its genetic components and molecular cellular mechanisms in a medical context. ICMM currently comprises five research programs, three high profile Research Centers as well as a number of international research groups.
https://icmm.ku.dk/english/
Terms of employment
The average weekly working hours are 37 hours per week.
The position is a fixed-term position limited to a period of around 5 years depending on the start date. The start date is April 1, 2026, or after agreement.
Employment will be in accordance with the provisions of the collective agreement between the Danish Ministry of Finance and AC (the Danish Confederation of Professional Associations). The monthly salary will be based on the number of years of work experience (seniority) with the possibility to negotiate a salary supplement based on prior experience and qualifications. The employer will pay an additional 18,07% to your pension fund.
Questions
For further information regarding the position, please contact Jesper V. Olsen, jesper.olsen@cpr.ku.dk
Application
Your application should in [English/Danish] include:
- Letter of application addressing the requirements (max. one page).
- Curriculum Vitae
- A certified/signed copy of certificate(s) of education
Application deadline: Sunday 4 January 2026 23.59 CET
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
Interviews are expected to be held in weeks 4 and 5
The University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.